$0.185
Opened: 18-Feb-2022
Shares Held at Open: 13,631,579
What does ALA do?
Arovella Therapeutics (ASX:ALA) is an early stage biotech research company seeking to develop an off-the-shelf cancer cell therapy treatment - part of the broader field of cancer immunotherapy.
What is the macro theme?
Cancer cell therapy is a burgeoning industry and the next frontier of cancer treatments.
The worldwide spend on cancer therapies is immense and cancer immunotherapy, and cell therapy in particular, hope to unlock new avenues for treatment that are more efficient, more readily available, and ultimately, more successful at treating cancer.
Our Big Bet for ALA
ALA achieves a major breakthrough in cancer immunotherapy, and is acquired by a major pharmaceutical company for multiples of our Initial Entry Price.
Why did we invest in ALA?
New technology to treat cancer with large commercial upside
Cancer cell therapies exist today, but it is in a form that is inefficient, expensive and unreliable - it needs to be individualised to each patient and can cost up to $500K.
ALA's technology aims to produce an ‘off-the-shelf’ treatment that can be produced using healthy, non-patient specific engineered cells, which if successful, will have significant commercial value.
Team with strong track record behind the project
We are impressed with the board and CEO. Chairman Paul Hopper has backed a number of successful ASX-listed biotechs including Imugene (1,160% returns in under 2 years).
Cornerstone ALA investor Merchant Funds Management has an impressive track record in biotech investing.
Licensed technology from top research institutions
The two primary technologies that ALA has licensed both come from top cancer research institutions, the Imperial College in London and MD Anderson Cancer Center.
What do we expect ALA to deliver?
Objective #1: Prepare for Phase-1 clinical trial for treatment #1
Preclinical studies have been completed for ALA’s first treatment (CAR19-iNKT) and we expect ALA to spend the next 12-18 months preparing for a Phase I clinical trial.
This involves completing the manufacturing milestones for the treatment, completing the trial design and securing ethics approval.
Objective #2: Undertake preclinical trials to confirm safety and specificity of treatment #2
ALA will need to confirm that it’s second treatment (DKK1-CAR/mAb), can successfully combine with the iNKT technology and that it does not target healthy cells.
We expect ALA to do this through a preclinical study in mice.
Objective #3: Explore complementary licensing opportunities
ALA’s board has deep knowledge of the cancer immunotherapy market. If a compelling opportunity to licence further tech for their portfolio emerges, we want to see ALA expand on their existing base of technology.
Objective #4: Prepare for Phase-1 clinical trial for Solid Tumour Therapy (with Imugene)
We expect ALA to conduct proof of concept studies and commence IND-enabling studies for ALA-101 + onCARlytics. These include in vivo (test tube) and in vitro (mice) studies that form the basis for an IND application, which is a requirement for ALA to commence a Phase 1 clinical trial. [Added 2-Feb-2023]
What could go wrong?
Early Stage Biotech Risk
There are some standard risks that are associated with early stage biotechs, although the treatment appears effective in mice, this might not translate to humans. Key risks:
Competition risk
There are a large number of companies targeting cancer cell therapies. If a company makes a breakthrough targeting the same disease or using a similar technology to ALA, it may damage the commercial value of ALA’s technology.
Manufacturing risk
As ALA has licensed cutting edge technologies, it may encounter difficulties in the manufacturing process. These could include hurdles found in the manufacturing partner selection process or difficulties scaling the process.
Funding risk
ALA says it is fully funded to prove out the safety profile and get initial manufacturing going through to Phase I trials, but should additional research be needed or manufacturing hurdles encountered, ALA may need to raise more funds before Phase I trials can commence.
Market Risk
We have added this risk to the ALA investment memo going forward.
Biotechs have been out of favour for a long period and this likely impacted ALA’s share price performance, and may impact it in the future.
The market risks for ALA are linked directly to funding risk as capital markets for biotechs remain constrained.
What is our investment plan?
We plan to patiently wait with our investment as the company delivers on the above objectives towards its next major catalyst, which for ALA is the commencement of Phase I clinical trials in the first half of 2023.
We will hold the majority of our position into the Phase I trial and re-assess our investment based on the results. As with all our early stage investments we will look to take some profit in the lead up to the key catalyst event, looking to sell ~20% of our position.
Disclosure: The authors of this article and owners of Next Investors and Finfeed, S3 Consortium Pty Ltd, and associated entities, own 13,631,579 ALA shares. S3 Consortium Pty Ltd has been engaged by ALA to share our commentary on the progress of our investment in ALA over time.
ALA’s cell targeting cancer treatment works in mice - human trials on track with manufacturing scale now achieved
Jun 7, 2024
Jun 7, 2024 |
10 min
Our biotech Investment, Arovella Therapeutics (ASX: ALA) is developing an iNKT cell therapy platform to fight cancer, and is setting the stage for a Phase 1 clinical trial. Basically ALA’s treatment can find, identify and kill specific cancer cells, leaving other healthy cells unharmed,
ALA now funded to enter Phase 1 trial to test new cancer treatment tech on humans…
Mar 26, 2024
Mar 26, 2024 |
12 min
Our Investment ALA is trialling a technology to find, target and attack ONLY cancer cells, leaving the rest of the body healthy and unimpacted.
ALA Bolts on New Technology in Cancer Fighting Cell Therapy Platform
Jan 30, 2024
Jan 30, 2024 |
11 min
Arovella Therapeutics (ASX:ALA) licensed a new technology today that promises to significantly boost the effectiveness of the company’s solid tumour therapy.
ALA is our best performing stock in 2023 - here’s why, and what to expect in 2024
Dec 21, 2023
Dec 21, 2023 |
12 min
The best stock in our portfolio this year was Arovella Therapeutics (ASX: ALA), growing 475% since the start of the year.
New Deal: ALA can now target lung cancer, pancreatic cancer, gastric cancer
Oct 12, 2023
Oct 12, 2023 |
13 min
Our preclinical biotech Investment, Arovella Therapeutics (ASX: ALA) has just announced that its cancer fighting cell-therapy may now also be able to more effectively target pancreatic, gastric and lung cancer.
ALA’s Positive Pre-IND FDA Meeting
Aug 7, 2024
Aug 7, 2024 |
3 min
Our cancer fighting biotech, Arovella Therapeutics (ASX: ALA) has been one of our best performing Investments.
Arovella Adds Esteemed CAR-iNKT Cell Pioneer
Apr 4, 2024
Apr 4, 2024 |
58.4 seconds
Yesterday, our preclinical biotech Arovella Therapeutics (ASX: ALA) appointed Professor Gianpietro Dotti to its Scientific Advisory Board.
ALA to Present Data at Prestigious Conference
Mar 27, 2024
Mar 27, 2024 |
1 min
Our cancer fighting preclinical biotech Arovella Therapeutics (ASX: ALA) announced that it will be presenting data at the prestigious American Association for Cancer Research (AACR) Annual Meeting.
ALA completes key manufacturing milestone
Jan 2, 2024
Jan 2, 2024 |
1 min
Our biotech Investment Arovella Therapeutics (ASX: ALA) just took another step closer to clinical studies for its cancer cell therapy treatments.
Arovella presents new data
Dec 12, 2023
Dec 12, 2023 |
3 min
Arovella Therapeutics (ASX: ALA) announced that it had presented data at a prestigious haematology conference in San Francisco.
Is it Bull o’clock yet?
Aug 18, 2024
Aug 18, 2024 |
20 min
Markets move in cycles. Right now, in the ASX small cap market, it feels like we are still firmly in “bear” mode. Equities prices have collapsed, liquidity too… But there have been signs that the gears on the crash-boom clock are turning ever closer towards “bull” mode.
What is next for the Market?
Aug 3, 2024
Aug 3, 2024 |
14 min
Well, that was a rough week in the markets. Particularly the last two days of trading.
Are the Markets Back and will it Continue...?
Jul 13, 2024
Jul 13, 2024 |
13 min
We’ll try not to jinx it. But this was the second week in a row where our Portfolio and watchlist was more green than red…
Gonna party like it’s FY25
Jul 8, 2024
Jul 8, 2024 |
15 min
Happy new financial year. The first week of trading in the new FY is done.
And what is Next for our Investments?
Jun 22, 2024
Jun 22, 2024 |
14 min
A total of ~35 hours of open market horrors of “June tax loss selling” for small cap investors to endure. Or… Could this be that glorious week towards the end of June when bargain hunting buyers outweigh the tax loss sellers?
